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Opposite affect which. This disturbed environment could directly have an influence on the ovary during the prenatal period and create the characteristic morphology of PCOS. Moreover, in rodents, prenatal testosterone exposure reduces foetal and placental growth Sathishkumar et al.
The present thinking leans more towards an epigenetic phenomenon involving a hyperexposure of the female foetus in utero to testosterone influencing the expression of genes, mainly those concerned with ovarian steroid production, insulin action and GnRH pulsatility.
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